Cirrhosis is a common disease with many causes, including anger, excessive alcohol consumption, and improper diet. Improving this condition requires not only medication but also changing unhealthy habits. What are the causes of autoimmune cirrhosis? The following is a detailed explanation to help you understand this issue.
Etiology of autoimmune cirrhosis:
The pathogenesis of autoimmune hepatitis remains unclear. Currently, genetics is considered a major contributing factor, with genetic susceptibility influencing the body's immune response to autoantigens and its correlation with clinical manifestations. Human leukocyte antigen (HLA) and DR are independent risk factors for autoimmune hepatitis. Infections from viruses, drugs, and the environment can act as triggering factors, contributing to the development of autoimmune hepatitis. Patients with autoimmune hepatitis experience a reaction to their own hepatocyte antigens due to impaired immune regulation, manifesting as cell-mediated cytotoxicity and an immune response resulting from the binding of hepatocyte surface-specific antigens to autoantibodies, with the latter being the predominant factor.
Traditional Chinese medicine (TCM) classifies autoimmune cirrhosis under the categories of "hypochondriac pain," "jaundice," "bi syndrome," "yin-yang toxins," and "asthenia." Its main etiology and pathogenesis are: inherent deficiency; acquired malnutrition or prolonged emotional depression; and subsequent exposure to damp-heat toxins or adverse medical conditions, leading to internal accumulation of heat toxins that invade the blood vessels, causing blood stasis and obstruction of meridian flow. The heat toxins deplete yin, resulting in yin deficiency and blood loss, while blood stasis further obstructs yang qi. This leads to liver and spleen dysfunction, transforming into autoimmune cirrhosis and causing various critical conditions.
After understanding the causes of autoimmune cirrhosis, it is important to choose the right treatment method when improving this type of cirrhosis. Moreover, this type of cirrhosis treatment is also a long-term process, so patients must be patient and accept the treatment. During the treatment process, patients must also improve their temperament, otherwise it is easy to aggravate the condition.